Nov 27, 2024
In this CME podcast, Dr. Andrew
Cutler interviews Dr. Jonathan Meyer about the history of muscarinic receptor
science in schizophrenia and how that informs the mechanisms of
action of novel muscarinic-targeting drugs for this disorder. They
also discuss the efficacy and safety of these drugs and provide practical strategies for
prescribing xanomeline-trospium.
Target Audience: This activity has been
developed for the healthcare team or individual prescriber
specializing in mental health. All other healthcare team members
interested in psychopharmacology are welcome for advanced
study.
Learning Objectives: After completing this
educational activity, you should be better able to:
- Discuss the history of muscarinic receptor science and the role
of muscarinic receptors in schizophrenia treatment - Differentiate novel and in-development muscarinic-targeting
treatments for schizophrenia based on their unique mechanisms of
action, efficacy, and tolerability data
Accreditation: In support of improving
patient care, Neuroscience Education Institute (NEI) is jointly
accredited by the Accreditation Council for Continuing Medical
Education (ACCME), the Accreditation Council for Pharmacy Education
(ACPE), and the American Nurses Credentialing Center (ANCC), to
provide continuing education for the healthcare team.
Activity Overview: This activity is available
with audio and is best supported via a computer or device with
current versions of the following browsers: Mozilla Firefox, Google
Chrome, or Safari. A PDF reader is required for print publications.
A post-test score of 70% or higher is required to receive CME/CE
credit.
Estimated Time to Complete: 1 hour
Released: November 27, 2024*
Expiration: November 26, 2027
*NEI maintains a record of participation for six (6)
years.
CME/CE Credits and Certificate Instructions:
After listening to the podcast, to take the optional posttest and
receive CME/CE credit, click: https://nei.global/POD24-SCHIZ01
Credit Designations: The following are being
offered for this activity:
- Physician: ACCME AMA PRA Category 1
Credits™ - NEI designates this enduring material for a maximum of
1.0 AMA PRA Category 1 Credit™. Physicians should
claim only the credit commensurate with the extent of their
participation in the activity - Nurse: ANCC contact hours
- NEI designates this Enduring Material for a maximum of 1.0 ANCC
contact hour - Nurse Practitioner: ACCME AMA PRA Category 1
Credit™ - American Academy of Nurse Practitioners National Certification
Program accepts AMA PRA Category 1 Credit™ from
organizations accredited by the ACCME. - The content in this activity pertaining to pharmacology is
worth 1.0 continuing education hour of pharmacotherapeutics. - Pharmacy: ACPE application-based contact
hours - This internet enduring, knowledge-based activity has been
approved for a maximum of 1.0 contact hour (.10 CEU). - The official record of credit will be in the CPE
Monitor system. Following ACPE Policy, NEI must transmit your claim
to CPE Monitor within 60 days from the date you complete this CPE
activity and is unable to report your claimed credit after this
60-day period. - Physician Associate/Assistant: AAPA Category 1 CME
credits 
NEI has been authorized by the
American Academy of PAs (AAPA) to award AAPA Category 1 CME credit
for activities planned in accordance with the AAPA CME Criteria.
This internet enduring activity is designated for 1.0 AAPA Category
1 credit. Approval is valid until November 26, 2027. PAs should
only claim credit commensurate with the extent of their
participation.- Psychology: APA CE credits
Continuing Education
(CE) credits for psychologists are provided through the
co-sponsorship of the American Psychological Association (APA)
Office of Continuing Education in Psychology (CEP). The APA CEP
Office maintains responsibility for the content of the
programs.- Social Work: ASWB-ACE CE credits
- As a Jointly Accredited Organization, NEI is approved to offer
social work continuing education by the Association of Social Work
Boards (ASWB) Approved Continuing Education (ACE) program.
Organizations, not individual courses, are approved under this
program. Regulatory boards are the final authority on courses
accepted for continuing education credit. Social workers completing
this internet enduring course receive 1 general continuing
education credits. - Non-Physician Member of the Healthcare Team:
Certificate of Participation - NEI awards hours of participation (consistent with the
designated number of AMA PRA Category 1 Credit(s)™)
to a participant who successfully completes this educational
activity. - Interprofessional Continuing Education: IPCE credit for
learning and change 
This activity was planned
by and for the healthcare team, and learners will receive 1
Interprofessional Continuing Education (IPCE) credit for learning
and change.
Peer Review: The content was peer-reviewed
by an MD specializing in psychiatry and psychopharmacology — to
ensure the scientific accuracy and medical relevance of information
presented and its independence from commercial bias. NEI takes
responsibility for the content, quality, and scientific integrity
of this CME/CE activity.
Disclosures: All individuals in a position
to influence or control content are required to disclose any
relevant financial relationships.
Faculty Author / Presenter
Andrew J. Cutler, MD
Clinical Associate Professor, Department of Psychiatry and
Behavioral Sciences, Norton College of Medicine, State University
of New York Upstate Medical University, Syracuse, NY
Chief Medical Officer, Neuroscience Education Institute,
Malvern, PA
Consultant/Advisor: AbbVie, Acadia, Alfasigma, Alkermes, Axsome,
Biogen, BioXcel, Boehringer Ingelheim, Brii Biosciences, Cerevel,
Corium, Delpor, Evolution Research, Idorsia, Intra-Cellular,
Ironshore, Janssen, Jazz, Karuna, Lundbeck, LivaNova, Luye,
MapLight Therapeutics, Neumora, Neurocrine, NeuroSigma, Noven,
Otsuka, Relmada, Reviva, Sage Therapeutics, Sumitomo (Sunovion),
Supernus, Takeda, Teva, Tris Pharma, VistaGen Therapeutics
Speakers Bureau: AbbVie, Acadia, Alfasigma, Alkermes, Axsome,
BioXcel, Corium, Idorsia, Intra-Cellular, Ironshore, Janssen,
Lundbeck, Neurocrine, Noven, Otsuka, Sumitomot (Sunovion),
Supernus, Takeda, Teva, Tris Pharma, Vanda
Data Safety Monitoring Board (DSMB): COMPASS Pathways, Freedom
Biosciences
Faculty Author / Presenter
Jonathan M. Meyer, MD
Voluntary Clinical Professor, Department of Psychiatry,
University of California, San Diego School of Medicine, La Jolla,
CA
Consultant/Advisor: AbbVie, Alkermes, Bristol Myers Squibb,
Intra-Cellular, Neurocrine, Sumitomo, Teva
Speakers Bureau: AbbVie, Alkermes, Axsome, Bristol Myers Squibb,
Intra-Cellular, Neurocrine, Teva
The remaining Planning Committee members, Content Editors, Peer
Reviewer, and NEI planners/staff have no financial relationships to
disclose. NEI planners and staff include Caroline O’Brien, Gabriela
Alarcón, PhD, Meghan M. Grady, BA, Andrea Zimmerman, EdD, CHCP, and
Brielle Calleo.
Disclosure of Off-Label Use: This
educational activity may include discussion of unlabeled and/or
investigational uses of agents that are not currently labeled for
such use by the FDA. Please consult the product prescribing
information for full disclosure of labeled uses.
Cultural Linguistic Competency and Implicit
Bias: A variety of resources addressing cultural and
linguistic competencies and strategies for understanding and
reducing implicit bias can be found in this handout—download
me.
Contact Us: For questions regarding this
educational activity, or to cancel your account, please
email [email protected].
Support: This activity is supported by an
educational grant from Bristol Myers Squibb.
